Fusion-driven sarcomas are devastating cancers that primarily affect children and young adults. These tumours are caused by the fusion of two chromosomes, resulting in the creation of abnormal proteins known as oncofusions.

Our research aims to dissect the function of these oncofusions, which act as chimeric transcription factors and investigate how they alter gene expression. By doing so, we seek to uncover the fundamental mechanisms underlying these tumours and use this knowledge to improve current diagnostic and develop biology-informed therapeutic approaches.